Half-lives / Retatrutide
Retatrutide half-life
≈ 6 days (144 hours ≈ 6 days) — computed decay curve below, primary source cited.
| Half-life | ≈ 6 days |
|---|---|
| ~97% cleared (5 half-lives) | ≈ 30 days |
| Typical route (published research) | SubQ · weekly |
Source: Retatrutide phase-2 pharmacokinetics (Jastreboff, NEJM 2023; half-life ≈6 days)
Frequently asked
How long does Retatrutide stay in your system?
With a half-life of ≈ 6 days, roughly 97% of a single Retatrutide dose is cleared after five half-lives — about 30 days. Repeated dosing accumulates and takes correspondingly longer to clear.
What does a ≈ 6 days half-life mean in practice?
Every 6 days, the remaining amount halves: 100% → 50% → 25% → 12.5%, and so on. The curve above plots exactly this decay for a single dose.
Where does this Retatrutide half-life number come from?
Retatrutide phase-2 pharmacokinetics (Jastreboff, NEJM 2023; half-life ≈6 days). We cite a primary source for every half-life we publish and version every change.
Related: Retatrutide reconstitution calculator · Retatrutide dose charts
Guides mentioning Retatrutide
See your own estimated levels
The Zyra Labs app plots this curve from the doses you actually log — accumulation, overlaps, and all — on your device, free to start.
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